Standardized to the European Reference Material for the Cystatin C (code: ERM®-DA471/IFCC), of the Institute for Reference Materials and Measurements (IRMM).

Kinetic UDR Immunoassay, enhanced with polystyrene particles, for their use on Beckman Coulter's IMMAGE® 800 Immunochemical Systems.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of the Cystatin C (Serum and Urine)

Cystatin C production rate is very constant (only somewhat affected by thyroid dysfunction and certain drugs, and independent of anthropometric variables, such as weight, muscle mass, etc.). Its level in plasma, or serum, correlates inversely with glomerular filtration rate (GFR), thus making it an excellent marker for its estimation using the appropriate equations.

Referencing the levels of other analytes to Cystatin C is a good way to free it from the effect of an eventual deterioration of glomerular function. This may be applicable in the case of quantitation of other low molecular weight proteins or drugs. For example, the ß2-microglobulin/Cystatin-C ratio has been reported to be a good indicator of lymphoproliferation levels.

Cys C, Glomerular function, Tubular disfunction, ERM, IMMAGE® Beckman Coulter, PENIA, Turbidimetric Immunoassays, TIA.